alexa Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged.


Journal of Blood Disorders & Transfusion

Author(s): Tripodi A, Primignani M, Mannucci PM

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Abstract Chronic liver disease is characterized by a global hemostatic defect including platelet-vessel wall interaction (primary hemostasis), coagulation and fibrinolysis that may cause abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with the timing and incidence of actual bleeding. In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field. This article was published in Intern Emerg Med and referenced in Journal of Blood Disorders & Transfusion

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