alexa Accessing the aortopulmonary window (#5) and the paraaortic (#6) lymph nodes in patients with non-small cell lung cancer.


Journal of Cancer Science & Therapy

Author(s): Cerfolio RJ, Bryant AS, Eloubeidi MA

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Abstract BACKGROUND: The purpose of this study was to assess the efficacy of the different techniques of lymph node biopsies in patients with suspected metastatic non-small cell lung cancer (NSCLC) in the subaortic (station #5) and paraaortic (station #6) lymph nodes. METHODS: This was a retrospective cohort study conducted of a prospective database of patients between January 2003 and June 2006 with suspected N2 disease only in the #5 or #6 lymph nodes, or both. All patients had integrated 2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography, and nodal biopsy or thoracotomy, or both, with complete thoracic lymphadenectomy. RESULTS: There were 112 patients with clinically suspected N2 disease in lymph node stations #5 or #6, or both. The primary tumor was in the left upper lobe in 98 (88\%) and in the left lower lobe in 14 (13\%), and 58 had pathologic N2 disease in #5 or #6 lymph node stations only. Mediastinoscopy, used in all patients found, unsuspected N3 disease in 4 patients (3.6\%) and N2 (#4L) disease in 12 (11\%). Endoscopic ultrasound with fine needle aspiration (EUS-FNA), implemented in 62 patients (56\%), correctly identified 41 patients (66\%). Left single-incision video-assisted thoracic surgery (VATS) was used in 39 patients and was correct in 100\%. Of the 58 patients, 53 (91\%) completed neoadjuvant chemoradiotherapy, followed by resection, and their 5-year survival was 64\%. CONCLUSIONS: EUS-FNA is less accurate for the #5 and #6 lymph node stations than left VATS. We prefer left VATS over the Chamberlain procedure for patients with suspected nodal metastases isolated only to #5 or #6 stations, and if positive, we prefer neoadjuvant therapy. The advantage of neoadjuvant therapy followed by resection compared with resection followed by adjuvant therapy remains controversial; and hence, the role for biopsy of these nodes is also controversial. This article was published in Ann Thorac Surg and referenced in Journal of Cancer Science & Therapy

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