Author(s): Absalom A, Amutike D, Lal A, White M, Kenny GN
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Abstract BACKGROUND: A prototype paediatric propofol target-controlled infusion (TCI) system, the 'Paedfusor' has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures. METHODS: Twenty-nine children aged 1-15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor. RESULTS: The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1\% and 9.7\%, respectively and the median value for wobble was 8.3\%. These values are much better than those found with the adult 'Diprifusor' system. CONCLUSION: The Paedfusor performance was found to be within the accepted limits for use as a TCI system.
This article was published in Br J Anaesth
and referenced in Pediatrics & Therapeutics