alexa Aceclofenac: A Potent Non-Steroidal Anti-Inflammatory Drug
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): Swarnlata Saraf, Deependra Singh, Gopal Garg, Swarnlata Saraf

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The pain management is always a problem for a physician and the search for a safe and effective option is still on.Although cyclooxygenase-2 selective inhibitors (coxibs) represent a new class of analgesic and anti-inflammatory drugs that exhibits preference for inhibition of cyclooxygenase-2, its cardiovascular safety is controversial, since trial showed increased incidence of cardiovascular events in patients receiving coxibs. There is a need of a drug, which has high efficacy like traditional NSAIDs, shows high GI tolerability like selective cox-2 inhibitors but have no adverse cardiovascular effects.Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities, similar to indomethacin and diclofenac and due to its preferential cox-2 blockade it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system.

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This article was published in Opan journal of inorganicNon-metalilc material and referenced in Journal of Chromatography & Separation Techniques

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