alexa Acetazolamide therapy in a case of fingolimod-associated macular edema: early benefits and long-term limitations.


Medicinal Chemistry

Author(s): Schrder K, Finis D, Harmel J, Ringelstein M, Hartung HP,

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Abstract Fingolimod is a potent drug in relapsing forms of multiple sclerosis. Visual impairment due to fingolimod-associated macular edema (FAME) usually leads to discontinuation of fingolimod therapy. METHODS: We report on a 24-year old woman with bilateral FAME. RESULTS: We continued fingolimod and added oral acetazolamide, which led to recovery of visual acuity and regression of macular edema. However, fingolimod had to be discontinued when fluorescein angiography revealed an enlarged foveal avascular zone. DISCUSSION AND CONCLUSION: Oral acetazolamide might be a treatment option for FAME, while ischemic conversion may be limiting. Ophthalmologic assessments are mandatory for follow-up when fingolimod therapy is continued after onset of FAME. Copyright © 2015 Elsevier B.V. All rights reserved. This article was published in Mult Scler Relat Disord and referenced in Medicinal Chemistry

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