alexa Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.


Journal of Nutrition & Food Sciences

Author(s): Sakakibara S, Yamauchi T, Oshima Y, Tsukamoto Y, Kadowaki T

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Abstract Acetic acid (AcOH), which is a short-chain fatty acid, is reported to have some beneficial effects on metabolism. To test the hypothesis that feeding of AcOH exerts beneficial effects on glucose homeostasis in type 2 diabetes, we fed either a standard diet or one containing 0.3\% AcOH to KK-A(y) mice for 8 weeks. Fasting plasma glucose and HbA1c levels were lower in mice fed AcOH for 8 weeks than in control mice. AcOH also reduced the expression of genes involved in gluconeogenesis and lipogenesis, which is in part regulated by 5'-AMP-activated protein kinase (AMPK) in the liver. Finally, sodium acetate, in the form of neutralized AcOH, directly activated AMPK and lowered the expression of genes such as for glucose-6-phosphatase and sterol regulatory element binding protein-1 in rat hepatocytes. These results indicate that the hypoglycemic effect of AcOH might be due to activation of AMPK in the liver. This article was published in Biochem Biophys Res Commun and referenced in Journal of Nutrition & Food Sciences

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