alexa Activating autoantibodies and cardiovascular disease.


Lupus: Open Access

Author(s): Luft FC

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Stimulating antibodies against G-protein-coupled receptors, including the β1- and β2-adrenergic receptors, the α1-adrenergic receptor, and the angiotensin II AT1 receptor, have been described, as well as activating antibodies directed at the platelet-derived growth factor receptor tyrosine kinase. Their existence and actions appear to be established. Lacking are mechanistic studies of receptor activation and translational studies to document receptor-stimulating antibodies as worthwhile therapeutic targets.

This article was published in Physiology (Bethesda) and referenced in Lupus: Open Access

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