alexa Activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the basilar artery after subarachnoid hemorrhage in rats.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Wang Z, Chen G, Zhu WW, Zhou D

Abstract Share this page

Abstract Cerebral vasospasm plays a pivotal role in the outcome of patients suffering from subarachnoid hemorrhage (SAH). The mechanisms underlying cerebral vasospasm are complex and interrelated. Previous studies that focused on only one of these mechanisms have proved to be ineffective in clinical practice. Therefore, a therapeutic target is desirable that can interrupt the multi-mechanisms underlying cerebral vasospasm. Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a key regulator in reducing oxidative stress, inflammatory damage, and accumulation of toxic metabolites, which are all involved in SAH-induced cerebral vasospasm. However, whether Nrf2 is activated in the cerebral artery after SAH hasn't been studied. In the present study, 30 male rats were randomly divided into two groups: control group (n = 15) and SAH group (n = 15). The animals in the SAH group were subjected to injection of autologous blood into the cisterna magna twice on day 0 and day 2 and were killed on day 5. The cross-sectional area of the basilar artery was measured and the nuclear Nrf2 protein level was studied by Western blot, electrophoretic mobility shift assay (EMSA), and immunohistochemical techniques. The expression of nuclear Nrf2 protein was increased remarkably in the SAH group compared with the control group. Immunohistochemical staining demonstrated that high level expression of Nrf2 was present in endothelial and smooth muscle cells; it was located in both the nuclei and cytoplasm. The results of this study indicate that Nrf2 expression is up-regulated in the cerebral artery of rats after experimental SAH.
This article was published in Ann Clin Lab Sci and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords