alexa Activation of phosphatidylinositol turnover by neurotensin receptors in the human colonic adenocarcinoma cell line HT29.
Oncology

Oncology

Cancer Surgery

Author(s): Amar S, Kitabgi P, Vincent JP, Amar S, Kitabgi P, Vincent JP

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Abstract Association of neurotensin to its receptor in HT29 cells increases the intracellular concentration of inositol phosphates. A rapid (20-30 s), transient stimulation of inositol trisphosphate (275\% of the basal level) and inositol bisphosphate (420\%) is first observed, followed by a slower, stable increase in inositol monophosphate (170\%). Half-maximal stimulation of the three inositol phosphates was obtained with 50-100 nM neurotensin. These results indicate that neurotensin is able to regulate intracellular Ca2+ levels in HT29 cells by using inositol trisphosphate as a second messenger.
This article was published in FEBS Lett and referenced in Cancer Surgery

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