alexa Activity-stress induces atrophy of apical dendrites of hippocampal pyramidal neurons in male rats.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Lambert KG, Buckelew SK, StaffisoSandoz G, Gaffga S, Carpenter W,

Abstract Share this page

Abstract Recently, researchers have demonstrated the damaging effect of restraint-stress on hippocampal neurons. The purpose of the present study was to determine if a more chronic stressor, i.e., activity-stress (A-S), would also result in hippocampal dendritic atrophy. When activity-stress (n = 6) rats showed evidence of the criteria "stress symptoms" (after an average of 6 days), they were sacrificed and their brains were quickly removed, blocked, and placed in Golgi-Cox solution. Food-yoked control animals (n = 6) were sacrificed on the following day. Serial coronal sections (150 um) of the rostral hippocampus were cut so that the CA3 and CAI areas could be analyzed. Stressed short-shaft neurons were significantly shorter and had fewer branch points in CA1 and CA3 neurons than the control neurons. A similar nonsignificant trend was observed in long-shaft neurons. These data suggest that a short period of chronic stress (6 days as opposed to 21 days in prior studies) induces neuronal atrophy in the hippocampus.
This article was published in Physiol Behav and referenced in Journal of Clinical & Experimental Pharmacology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version