alexa Acute lupus myocarditis: clinical features and outcome of an oriental case series.
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Law WG, Thong BY, Lian TY, Kong KO, Chng HH

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Abstract Symptomatic myocarditis in systemic lupus erythematosus (SLE) is uncommon. We describe the clinical characteristics, management and outcomes of 11 SLE patients without any atherosclerotic risk factors, who presented with acute lupus myocarditis (ALM). All patients were female, 46\% Chinese with mean age of 27 +/- 10 years at diagnosis of SLE. ALM was one of the initial manifestations of SLE in eight (73\%) patients. The median duration from onset ALM to initiation of treatment was two weeks (range: 0.3-8). All had clinical feature of left ventricle dysfunction. The most common electrocardiographic feature was nonspecific ST/T wave changes (91\%). Common echocardiographic findings included segmental wall motion abnormalities (81\%) and decreased left ventricular ejection fraction (81\%). Median SLE disease activity index at presentation was 16 (range: 4-30). All patients received high dose corticosteroids and 64\% received intravenous pulse cyclophosphamide. There were two deaths (18\%) from infections. The remaining nine survivors had no recurrence of ALM nor suffer any SLE-related damage (median SLICC damage score of 0), up to a median follow-up of four years (range: 2.5-10.1). Repeat echocardiography after six months or later showed normal LVEF in eight patients (89\%). Early immunosuppressive therapy in ALM, with high dose corticosteroids and pulse intravenous cyclophosphamide, results in good cardiac outcome.
This article was published in Lupus and referenced in Journal of Clinical Case Reports

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