Author(s): Chugh KS, Malik GH, Singhal PC
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Abstract Two patients developed acute oliguric renal failure following paraphenylene-diamine intoxication. The associated clinical features included vomiting, angioneurotic edema, cyanosis, intravascular hemolysis and methemoglobinemia. Therapeutic dialysis and symptomatic management was followed by complete recovery in one, and death due to septicemia during the oliguric phase in the other patient. Renal histology in both cases revealed acute tubular necrosis. The pathogenetic mechanisms involved in the development of acute renal failure following paraphenylene-diamine have been discussed.
This article was published in J Med
and referenced in Journal of Addiction Research & Therapy