alexa Adalimumab therapy of psoriasis and psoriatic arthritis in a patient with cirrhosis of the liver.
Gastroenterology

Gastroenterology

Journal of Colitis & Diverticulitis

Author(s): Sarah Piel, Joachim Dissemond

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We report a 57-year-old male patient with psoriasis and psoriatic arthritis (PA), diabetes, and hereditary α-1-antitrypsin deficiency, resulting in histologically confirmed micronodular cirrhosis of the liver. Mutilating PA was diagnosed 11 years earlier, and a systemic treatment with methotrexate (MTX) was initiated. Because of a considerable elevation of liver enzyme levels, MTX had to be interrupted. A few years later, the patient started infliximab therapy. Although the skin and the PA showed a dramatic improvement, infliximab had to be discontinued because of severe thrombocytopenia.

This article was published in J Am Acad Dermatol. and referenced in Journal of Colitis & Diverticulitis

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