alexa ADAMTS13 activity levels in patients with human immunodeficiency virus-associated thrombotic microangiopathy and profound CD4 deficiency.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Park YA, Hay SN, Brecher ME, Park YA, Hay SN, Brecher ME

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Abstract BACKGROUND: Thrombotic microangiopathy (TMA) encompasses a number of disorders with hemolytic anemia and thrombocytopenia, including thrombotic thrombocytopenic purpura (TTP). A deficiency in ADAMTS13 enzyme levels, along with an inhibitory antibody, is found in most patients with idiopathic TTP. Patients with human immunodeficiency virus (HIV) infection can have a TTP-like illness; however, it appears to have a different etiology. METHODS: A retrospective review of patients who had an ADAMTS13 activity level performed from 2005 through 2007 was completed. Patients with a diagnosis of HIV infection with TMA were investigated. RESULTS: Two patients were identified. Case 1: a 47-year-old man with HIV infection and a CD4 count <10/microL presented with altered mental status, pneumonia, acute renal failure, thrombocytopenia, and anemia. The ADAMTS13 level was 71\%. He was treated with plasma infusion. Two days after admission, he expired because of respiratory distress syndrome and metabolic lactic acidosis. Case 2: a 39-year-old man with HIV infection and a CD4 count of 9/microL presented with chest pain, acute renal failure, thrombocytopenia, and anemia. The ADAMTS13 level was 65\%. He received multiple units of fresh frozen plasma without significant improvement in his platelet count. Six days after admission, the patient began highly active antiretroviral therapy, which resulted in a rapid increase in his platelet count. CONCLUSIONS: HIV-associated TMA is postulated to have a different pathophysiology than idiopathic TTP. This study supports that assumption because both patients exhibited many of the classic findings of TTP but did not have a deficiency of ADAMTS13. (c) 2009 Wiley-Liss, Inc. This article was published in J Clin Apher and referenced in Journal of AIDS & Clinical Research

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