alexa Adaptive evolution of highly mutable loci in pathogenic bacteria.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Moxon ER, Rainey PB, Nowak MA, Lenski RE

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Abstract Bacteria have specific loci that are highly mutable. We argue that the coexistence within bacterial genomes of such 'contingency' genes with high mutation rates, and 'housekeeping' genes with low mutation rates, is the result of adaptive evolution, and facilitates the efficient exploration of phenotypic solutions to unpredictable aspects of the host environment while minimizing deleterious effects on fitness.
This article was published in Curr Biol and referenced in Journal of Glycomics & Lipidomics

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