alexa Adaptive group sequential designs for clinical trials: combining the advantages of adaptive and of classical group sequential approaches.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Mller HH, Schfer H

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Abstract A general method is presented integrating the concept of adaptive interim analyses into classical group sequential testing. This allows the researcher to represent every group sequential plan as an adaptive trial design and to make design changes during the course of the trial after every interim analysis in the same way as with adaptive designs. The concept of adaptive trial designing is thereby generalized to a large variety of possible sequential plans.
This article was published in Biometrics and referenced in Pharmaceutica Analytica Acta

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