alexa Adenoid cystic carcinoma of the head and neck.

Oncology & Cancer Case Reports

Author(s): Balamucki CJ, Amdur RJ, Werning JW, Vaysberg M, Morris CG,

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Abstract PURPOSE: To report our experience using radiotherapy alone or combined with surgery to treat adenoid cystic carcinoma of the head and neck. MATERIALS AND METHODS: Radiotherapy alone or combined with surgery was used to treat 120 previously untreated patients with adenoid cystic carcinoma (ACC) of the head and neck from August 1966 to March 2008. Patients were treated with curative intent. American Joint Committee on Cancer stage distribution was,T0 (n = 1), T1 (n = 26), T2 (n = 25), T3 (n = 14), T4 (n = 54), N0 (n = 113), N1 (n = 2), N2a (n = 1), N2b (n = 2), and N2c (n = 2). Treatment included surgery with postoperative radiotherapy (n = 71), radiotherapy alone (n = 46), and preoperative radiotherapy and surgery (n = 3). Incidental and clinical perineural invasion was found in 41 (34\%) and 35 (29\%) patients, respectively. Median follow-up was 8.6 and 11.6 years overall and among living patients, respectively. RESULTS: The 10-year overall, cause-specific, and distant metastasis-free survival rates, respectively, were as follows: radiotherapy alone, 37\%, 46\%, and 76\%; surgery and radiotherapy, 57\%, 71\%, and 62\%; and overall, 50\%. The 10-year local control rates were as follows: radiotherapy alone, 36\%; surgery and radiotherapy, 84\%; and overall, 65\%. The 10-year neck control rates were as follows: elective nodal irradiation (ENI), 98\%; no ENI, 89\%; and overall, 95\%. CONCLUSIONS: Surgery and adjuvant radiotherapy offer the best chance for cure for patients with resectable adenoid cystic carcinomas of the head and neck. Some patients with advanced, incompletely resectable disease can be cured with radiotherapy alone. ENI should be considered for primary sites located in lymphatic-rich regions. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Am J Otolaryngol and referenced in Oncology & Cancer Case Reports

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