alexa Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Mojica P, Smith D, Ellenhorn J

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Abstract BACKGROUND: Gallbladder carcinoma is a rare malignancy and is associated with dismal outcomes. The aim of this study was to better define the role of adjuvant radiation therapy in the management of gallbladder carcinoma. METHODS: The Surveillance, Epidemiological, and End Results (SEER) survey from the National Cancer Institute was queried from 1992 to 2002. Retrospective analysis was done. The end-point of the study was overall survival. RESULTS: There were a total of 3,187 cases of gallbladder carcinoma in the registry from 1992 to 2002. Of the surgical group, 35\% were stage I, 36\% were stage II, 6\% were stage III, and 21\% were stage IV. Adjuvant radiation was used in 17\% of the cases. The median survival for those patients receiving adjuvant radiation therapy was 14 months compared to an 8 months median survival for those treated without adjuvant radiation therapy (P < or = 0.001). The survival benefit associated with radiation use was only presenting those patients with regional spread (P = 0.0001) and tumors infiltrating the liver (P = 0.011). CONCLUSION: The use of adjuvant radiation therapy is associated with improved survival in patients with locally advanced gallbladder cancer or gallbladder cancer with regional disease. Copyright 2007 Wiley-Liss, Inc. This article was published in J Surg Oncol and referenced in Journal of Cell Science & Therapy

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