alexa Adolescent cervical dysplasia: histologic evaluation, treatment, and outcomes.


Journal of Carcinogenesis & Mutagenesis

Author(s): Moore K, Cofer A, Elliot L, Lanneau G, Walker J,

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Abstract OBJECTIVE: The purpose of this study was to evaluate histologic findings and outcomes among adolescents with cervical dysplasia. STUDY DESIGN: Patient charts (2001-2005) were reviewed. Prevalence of cervical intraepithelial neoplasia (CIN) grades 2 and 3 and progression and regression were recorded. RESULTS: Five hundred one patients were identified. On biopsy, 324 patients (65\%) had CIN 1 or less, and 177 patients (35\%) had CIN > or = 2. Twenty-nine percent of the patients with CIN 2 opted for conservative treatment vs excision. Over 18 months, the condition of 65\% of the patients regressed; the condition of 20\% of the patients was stable, and the condition of 5\% of the patients progressed without cancer. Of the patients who underwent excision (follow-up median, 26 months), 84\% experienced regression of their condition; the condition of 11\% was persistent, and 5\% progressed with no cancer. CONCLUSION: CIN > or = 2 is present in 35\% of our cohort. Most had CIN 2, and most experienced regression. Our observation supports continued vigilance in the evaluation of adolescents but suggests that less intervention for CIN 2 may be acceptable. This article was published in Am J Obstet Gynecol and referenced in Journal of Carcinogenesis & Mutagenesis

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