alexa Adult-generated neurons exhibit diverse developmental fates.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Whitman MC, Greer CA

Abstract Share this page

Abstract In mammals, olfactory bulb (OB) interneurons, granule cells and periglomerular (PG) cells, are generated throughout adulthood. PG cells comprise a heterogeneous population in both morphology and molecular phenotypes. It is unknown whether adult genesis of PG cells occurs among all subtypes or is limited to a subpopulation. We show that within 2 weeks after retroviral labeling in the subventricular zone, two morphological populations of PG cells are found in the OB, one with large multi-glomerular dendritic arbors, and one with dendritic arbors limited to one or two glomeruli. On both types, immature dendritic spines are first evident at 4 weeks and mature, pedunculated spines by 6 weeks. To differentiate PG subpopulations we used expression of calcium binding proteins, GAD67 and tyrosine hydroxylase as markers. Among adult-born BrdU labeled cells, all molecular subtypes were represented, although GAD67 and tyrosine hydroxylase expressing cells were overrepresented proportional to their expression in the total PG cell population. During the time when spines are maturing, approximately half the PG cells are lost, in roughly equal proportions to their generation. Our data show the diverse developmental potential of SVZ neuroblasts and suggest that integration into synaptic circuits is necessary for survival. Copyright (c) 2007 Wiley Periodicals, Inc. This article was published in Dev Neurobiol and referenced in Journal of Cell Science & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords