alexa Advances in tenascin-C biology
Pathology

Pathology

Diagnostic Pathology: Open Access

Author(s): Midwood KS, Hussenet T, Langlois B, Orend G

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Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

This article was published in Cellular and Molecular Life Sciences and referenced in Diagnostic Pathology: Open Access

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