alexa Advantages and potential of lipid-membrane-incorporating fullerenes prepared by the fullerene-exchange method.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Author(s): Ikeda A, Mori M, Kiguchi K, Yasuhara K, Kikuchi J,

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Abstract Lipid-membrane-incorporating C(60) and C(70) (LMIC(60) and LMIC(70)) were prepared by the fullerene-exchange reaction from the γ-cyclodextrin cavity to vesicles (we call this method the "exchange method"). An advantage of this method is that the ratios of [C(60)]/[lipids] and [C(70)]/[lipids] can be arbitrarily controlled by adjusting the ratios of the fullerenes and liposome. The maximum ratio (30 mol\%) obtained was approximately 14 and 100 times higher than those achieved for LMIC(60) and LMIC(70) , respectively, that were prepared by the classical method, which we call the "premixing method" (dissolving lipids and C(60) or C(70) in chloroform, followed by concentration and extraction with water). Furthermore, the stabilities and photodynamic activities of the LMIC(60) and LMIC(70) solutions prepared by the exchange method were shown to be much higher than those prepared by the premixing method. That is, the exchange method was found to be superior to the premixing method as a preparative method of LMIC(60) and LMIC(70) for applications in photomedical and photomaterials chemistry. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in Chem Asian J and referenced in

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