alexa Adventure of recombinant human activated protein C in sepsis and new treatment hopes on the horizon
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): Selcuk Kaya

Abstract Share this page

Sepsis continues to be a very important cause of morbidity and mortality despite advances in modern medicine. It is the cause of mortality in approximately 28-50% of the patients, with the risk increasing particularly in patients with multiple organ dysfunctions. Although anti-infective treatment and securing hemostasis form the cornerstone in the management of this condition, studies to develop new drugs are expected to reduce mortality in severely septic patients. Recombinant human activated protein C (rhAPC) was known as an anti-inflammatory agent with proven efficacy in severe sepsis patients and had a critical effect in the reduction of mortality when administered in the right dose and duration so far, but unfortunately current studies indicate that it was unable to show favorable effects of rhAPC on patients with severe sepsis. For this reason, interests are becoming focused on some other new approaches such as antioxidant treatments, stem cells, computer-implemented sepsis alerting systems, endotoxin removal devices. These attempts may reduce the incidence of mortality due to sepsis in the near future. Some patents on sepsis have also been reviewed in this article.

This article was published in Recent Pat Inflamm Allergy Drug Discov and referenced in Clinical Microbiology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords