alexa Adverse drug reactions in inpatients of internal medicine wards at a tertiary care hospital: A prospective cohort study.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmaceutical Care & Health Systems

Author(s): Vora MB, Trivedi HR, Shah BK, Tripathi CB

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Abstract OBJECTIVE: To find out incidence of adverse drug reactions (ADR) in patients of internal medicine wards and study various aspects of ADR, e.g., causality, mortality, drugs commonly causing ADR in internal medicine wards of Guru Gobind Singh Hospital, Jamnagar, a tertiary care hospital. MATERIALS AND METHODS: This was prospective, observational study carried out at Department of Medicine, Shri Meghji Pethraj Shah Medical College attached with Guru Gobind Singh Hospital, a tertiary care teaching hospital, Jamnagar, Gujarat over a period of 6 months. For statistical analysis, ADR were analyzed by using Chi-square test. RESULTS: Out of total 860 patients admitted, 830 were analyzed as they met the inclusion criteria. A total of 45 (5.42\%) patients developed 47 ADR. Among them, 27 (3.25 \%) (95\% CI, 2.03, 4.47\%) patients due to ADR required hospital admission in medicine ward (ADR Ad), 18 (2.17\%) (95\% CI, 1.17\%-3.17\%) patients developed ADR while already hospitalized in medicine ward (ADR In). Most of the fatal and life-threatening reactions occurred due to chemotherapeutic agents. Majority of patients discontinued suspected drug and recovered from ADR. CONCLUSION: Fatal and life-threatening adverse reactions reported in the present as well as other studies underline the importance of such studies and need for creating awareness among health professionals about looking for and reporting such reactions.
This article was published in J Pharmacol Pharmacother and referenced in Journal of Pharmaceutical Care & Health Systems

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