alexa Adverse drug reactions: trends in a tertiary care hospital.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmaceutical Care & Health Systems

Author(s): Rehan HS, Chopra D, Sah RK, Mishra R

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Abstract BACKGROUND: Pharmacovigilance (PV) System is an integral part of drug therapy which helps in detection, monitoring and designing strategies to minimize the occurrence of adverse drug reaction (ADRs). Present study was planned to study the patterns of ADRs in a tertiary care government hospital. METHODS: The present study was carried out for a period of one year. Suspected adverse drug reaction reports due to medications submitted to the Department of Pharmacology under the Pharmacovigilance Programme of India were included. The reports were analyzed for their type, severity, organ system involvement, and the causality assessment was performed using Naranjo Probability Scale. RESULTS: A total of 520 ADRs were received. The highest percentage (66.2\%) of ADRs was seen in adult patients. Female patients experienced more (57.5\%) ADRs. 95\% of ADRs occurred in patients receiving 5 or more drugs. Medicine department reported the maximum number (38.46\%) of ADRs. Antimicrobial agents (AMA) (35.7\%) were the commonest group of drugs causing ADRs. Amongst the organ systems affected, skin constituted a major component (40.4\%). Causality assessment revealed that 55\% of the ADRs were possible. Majority of the ADRs were non-serious and only 7 cases were serious and required hospitalization. CONCLUSION: The results suggest that healthcare professionals (HCP) at this institution are cognizant of PV. However a closer liaison between the HCPs and the hospital PV centre, periodic reinforcement of the HCPs regarding the need for PV can further improve spontaneous reporting. The data will also help in designing strategies for framing policies towards safer use of drugs in future.
This article was published in Curr Drug Saf and referenced in Journal of Pharmaceutical Care & Health Systems

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