alexa Adverse events of intravenous immunoglobulin infusions: a ten-year retrospective study.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Palabrica FR, Kwong SL, Padua FR

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Abstract BACKGROUND: Intravenous immunoglobulin (IVIG) is a biological product with adverse effects that appears to vary considerably among different IVIG preparations. OBJECTIVES: To describe the adverse events of patients given intravenous immunoglobulin infusions. METHOD: Data was collected on all patients receiving IVIG infusion at a tertiary hospital from January 2001 to December 2010. Descriptive statistics was used. RESULTS: 77 patients (45 males, 32 females) received IVIG infusions. Thirty two percent (n = 25) experienced adverse reactions. The most common indication was Kawasaki disease (85.7\%) followed by immunodeficiency disorders (7.8\%). Majority of the patients were children, with the highest frequency of infusions among those aged 2 to 8 years old (52\%). 36 infusions were associated with occurrence of adverse effects. Fever was the most common adverse event (n = 11, 30.6\%), followed by rash (n = 8, 22.2\%) and chills (n = 7, 19.4\%). Other adverse events were cyanosis (n = 3, 8.3\%), hypotension (n = 2, 5.6\%), hypothermia (n = 2, 5.6\%), irritability (n = 1, 2.8\%), vomiting (n = 1, 2.8\%), and chest pain (n = 1, 2.8\%). Adverse events were observed to occur most frequently within 1 to 6 h from onset of IVIG infusion. Among the various IVIG preparations available locally (Gammagard, Kiovig, Gamimune, Veno-S & IV Globulin S), Gammagard was the brand frequently used (50.7\%). It also has the most number of adverse events, with 17 out of 41 (41.5\%) infusions resulting in adverse reactions. Most of the reactions occurred with fast infusion rates, and clinical manifestations subsided when the rate of infusion was reduced. CONCLUSION: In this study, thirty two percent of patients given IVIG infusions experienced adverse events. Fever was the most common manifestation. Symptoms occurred within 1 to 6 h from onset of infusion, were affected by fast infusion rates, and managed by reducing the rate of infusion.
This article was published in Asia Pac Allergy and referenced in Journal of Clinical & Cellular Immunology

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