Author(s): Frasca D, Diaz A, Romero M, Landin AM, Blomberg BB
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Abstract Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging. Copyright © 2010 Elsevier B.V. All rights reserved.
This article was published in Ageing Res Rev
and referenced in Journal of Phylogenetics & Evolutionary Biology