Author(s): Ranson RN, Dodds AL, Smith MJ, Santer RM, Watson AH
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Abstract The effects of ageing on the innervation patterns of lumbosacral spinal nuclei involved in controlling lower urinary tract functions, including micturition, were studied using immunohistochemistry for serotonin (5-HT) and tyrosine hydroxylase (TH) in male Wistar rats of 3 and 24 months. Quantitative image analysis revealed significant age-associated declines in the innervation of most regions including the intermediolateral cell nucleus, sacral parasympathetic nucleus, dorsal grey commissure and in the ventral horn including the dorsolateral nucleus which in the rat is one of the component nuclei homologous to Onuf's nucleus in man. Notable exceptions to this generalised decline were observed in the 5-HT innervation of the sacral parasympathetic nucleus, which was maintained, and in the region of the dorsolateral motor nucleus where TH-like immunoreactivity did not significantly decline. These results suggest that the changes in micturition characteristics observed in aged rats may in part be a consequence of the alterations in, and decline of, aminergic inputs to both autonomic and somatic spinal nuclei associated with bladder function.
This article was published in Brain Res
and referenced in Journal of Addiction Research & Therapy