alexa Age-dependent effects of lead on [3H]MK-801 binding to the NMDA receptor-gated ionophore: in vitro and in vivo studies.


Journal of Drug Metabolism & Toxicology

Author(s): Guilarte TR, Miceli RC

Abstract Share this page

Abstract Lead (Pb2+) is a more potent inhibitor of [3H]MK-801 binding to rat neuronal membranes than Zn2+ and Mg2+. The inhibitory effects of Pb2+ appeared to be age-dependent since the IC50 was significantly lower in cortical membranes prepared from neonatal than from adult rats. The results also indicate that the hippocampus is more sensitive than the cerebral cortex since the Pb2+ IC50 was significantly lower in the hippocampus. These findings suggest developmental and regional brain heterogeneity to the inhibitory action of lead on [3H]MK-801 binding. Chronic in vivo exposure to Pb2+ resulted in the loss of [3H]MK-801 binding sites in the cerebral cortex of neonatal but not of adult rats. These lead-induced changes may influence developmental processes requiring NMDA receptor activation.
This article was published in Neurosci Lett and referenced in Journal of Drug Metabolism & Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version