Author(s): Sedivy JM, Banumathy G, Adams PD
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Abstract Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
This article was published in Exp Cell Res
and referenced in Journal of Gerontology & Geriatric Research