alexa Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells.
Oncology

Oncology

Cancer Surgery

Author(s): Parisi C, Giorgi C, Batassa EM, Braccini L, Maresca G, , Parisi C, Giorgi C, Batassa EM, Braccini L, Maresca G,

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Abstract Argonaute are a conserved class of proteins central to the microRNA pathway. We have highlighted a novel and non-redundant function of Ago1 versus Ago2; the two core factors of the miRNA-associated RISC complex. Stable overexpression of Ago1 in neuroblastoma cells causes the cell cycle to slow down, a decrease in cellular motility and a stronger apoptotic response upon UV irradiation. These effects, together with a significant increase in p53 levels, suggest that Ago1 may act as a tumor-suppressor factor, a function also supported by GEO Profiles microarrays that inversely correlate Ago1 expression levels with cell proliferation rates. Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. This article was published in FEBS Lett and referenced in Cancer Surgery

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