alexa Air Leak is Associated with Poor Adherence to Autopap Therapy
Neurology

Neurology

Journal of Sleep Disorders & Therapy

Author(s): Alexandra Valentin, Shyam Subramanian, Stuart F Quan, Richard B Berry, Sairam Parthasarathy

Abstract Share this page

Study Objectives: To our knowledge, a systematic study of the effect of air leak on adherence to auto-titrating positive airway pressure (autoPAP) therapy has not been reported. We hypothesized that in patients with obstructive sleep apnea (OSA), greater levels of air leak were associated with poor adherence to autoPAP therapy.

Design: Retrospective cohort study

Setting: Academic Center

Participants: Ninety-six consecutive patients with high probability for OSA.

Interventions: N/A

Measurements: Patients with OSA received 1 week of autoPAP therapy following which both adherence data and air leak information was downloaded from the device. Continuous positive airway pressure (CPAP) therapy was issued for a 5-week period with pressure determined by 90th percentile of that delivered during autoPAP therapy. Adequate adherence was defined as average usage > 4 h per night on all nights.

Results: Forty-three patients were adherent to autoPAP therapy (350 ± 67[SD] min/day), whereas 53 patients were not (122 ± 65 min/day; P < 0.0001). Air leak that was adjusted for pressure delivered was greater in non-adherent patients (7.0 ± 3.5 L/min/cm H2O) than that in adherent patients (4.9 ± 1.7 L/min/cm H2O; P < 0.0001). Greater residual respiratory events (measured as autoPAP-derived hypopnea index) and proportion of time spent at large leak levels were associated with non-adherence. Patients who were adherent to autoPAP therapy received higher average therapeutic pressures from the autoPAP device than non-adherent patients. Multivariate logistic regression revealed that higher levels of air leak were associated with non-adherence to autoPAP therapy (odds ratio 1.43; 95% CI, 1.03, 1.98; P = 0.03). Moreover, adherence to autoPAP therapy was strongly correlated with subsequent adherence to CPAP therapy (R2 = 0.74; P < 0.0001).

Conclusion: Air leak was associated with poor adherence to autoPAP therapy. We speculate that air leak could be a potential target for future studies aimed at enhancing adherence to autoPAP therapy.

This article was published in Sleep and referenced in Journal of Sleep Disorders & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords