alexa AKT as locus of cancer angiogenic robustness and fragility.
General Science

General Science

Biological Systems: Open Access

Author(s): Radisavljevic Z, Radisavljevic Z

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Abstract Angiogenesis get full robustness in metastatic cancer, relapsed leukemia or lymphoma when complex positive feedback loop signaling systems become integrative. A cancer hypoxic microenvironment generates positive loops inducing formation of the vascular functional shunts. AKT is an upstream angiogenic locus of integrative robustness and fragility activated by the positive loops. AKT controls two downstream nodes the mTOR and NOS in nodal organization of the signaling genes. AKT phosphorylation is regulated by a balance of an oxidant/antioxidant. Targeting AKT locus represents new principle to control integrative angiogenic robustness by the locus chemotherapy. Copyright © 2012 Wiley Periodicals, Inc. This article was published in J Cell Physiol and referenced in Biological Systems: Open Access

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