Author(s): Costanzo S, Di Castelnuovo A, Donati MB, Iacoviello L, de Gaetano G
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Abstract OBJECTIVES: The purpose of this study was to quantify the relation between alcohol consumption and cardiovascular and total mortality in patients with a history of cardiovascular events. BACKGROUND: Regular, moderate alcohol consumption by healthy people is associated with lower cardiovascular and all-cause mortality. No extensive meta-analysis is presently available on the possible association of alcohol consumption with secondary events in patients with cardiovascular disease. METHODS: Articles were retrieved through October 2009 by search in PubMed and EMBASE. Fifty-four publications were identified, but only 8 were selected for our analyses, including 16,351 patients with a history of cardiovascular disease. Secondary events were cardiovascular or all-cause mortality. All selected studies were prospective. Data were pooled with a weighted, least-squares regression analysis of second-order fractional polynomial models. RESULTS: The meta-analysis on cardiovascular mortality showed a J-shaped pooled curve with a significant maximal protection (average 22\%) by alcohol at approximately 26 g/day. In the meta-analysis on mortality for any cause, J-shaped pooled curves were observed in the overall analysis (average maximal protection of 18\% in the range of 5 to 10 g/day) and in all subgroups according to either the type of patients or the characteristics of the studies. CONCLUSIONS: In patients with cardiovascular disease, light to moderate alcohol consumption (5 to 25 g/day) was significantly associated with a lower incidence of cardiovascular and all-cause mortality.
This article was published in J Am Coll Cardiol
and referenced in Journal of Antivirals & Antiretrovirals