alexa Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Yao T, Wu Z, Liu Y, Rao Q, Lin Z

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Abstract OBJECTIVE: To analyse the associations between aldehyde dehydrogenase 1 (ALDH1) tumour immunopositivity and disease-free survival in cervical carcinoma. METHODS: ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives. Data regarding disease-free survival were obtained. Kaplan-Meier survival analyses and Cox proportional hazards regression models were performed. RESULTS: Patients with ALDH1-positive tumours (n = 31) had significantly shorter disease-free survival than those with ALDH1-negative tumours (n = 167; 41.99 ± 0.90 vs 53.64 ± 2.67 months). ALDH1 positivity was associated with poor prognosis (relative risk 2.727; 95\% confidence intervals 1.253, 5.914). CONCLUSIONS: ALDH1 positivity is associated with poor prognosis of cervical carcinoma, and may be an independent predictor of prognosis. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. This article was published in J Int Med Res and referenced in Journal of Molecular and Genetic Medicine

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