alexa Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.


Immunotherapy: Open Access

Author(s): Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M

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Memory T cells promote allograft rejection particularly in co-stimulation blockade-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (lymphocyte function-associated antigen-3-Ig; LFA -3-Ig) selectively eliminates memory T cells and, when combined with a co-stimulation blockade-based regimen using cytotoxic T lymphocyte antigen-4 (CTLA-4)-Ig, a CD80- and CD86-specific fusion protein, prevents renal allograft rejection and alloantibody formation in nonhuman primates. These results support the immediate translation of a regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids or pan-T cell depletion. This article was published in 2009 and referenced in Immunotherapy: Open Access

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