alexa Alkaloids from catecholamines in adrenal tissue: possible role in alcoholism.


Journal of Neurological Disorders

Author(s): Cohen G, Collins M

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Abstract Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutral pH and room temperature to form 1,2,3,4-tetrahydroiso-quinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37 degrees C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.
This article was published in Science and referenced in Journal of Neurological Disorders

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