alexa Alkylation of H-phosphinate esters under basic conditions.
Chemistry

Chemistry

Chemical Sciences Journal

Author(s): AbrunhosaThomas I, Sellers CE, Montchamp JL

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Abstract An efficient and general procedure was developed for the direct alkylation of H-phosphinate esters with LHMDS at low temperature. The simplicity of the reaction allows the use of various H-phosphinate esters and takes place with a wide range of electrophiles. The approach can be employed to access some GABA analogues or precursors to GABA analogues. The isolated yields are moderate to good. This is the first report of an alkylation with a secondary iodide or a primary chloride.
This article was published in J Org Chem and referenced in Chemical Sciences Journal

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