Author(s): Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE
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Abstract Non-allergic bronchial hyper-reactivity is a feature of most patients with asthma. We have measured non-allergic bronchial reactivity to inhaled histamine and methacholine in thirteen asthmatic subjects before and after allergen inhalation in the laboratory. The allergen inhalation produced mild early asthmatic responses (19-40\% FEV1 fall) in all thirteen, additional definite late asthmatic responses (17-29\% FEV1 fall) in four, and equivocal late asthmatic responses (5-11\% FEV1 fall) in five. Following allergen inhalation, non-allergic bronchial reactivity increased in seven for up to 7 days. The seven included all four with definite late asthmatic responses and three of the five with equivocal late asthmatic responses. We conclude that allergens make asthma worse, partly through non-allergic mechanisms, and that avoidance of allergens is important in reducing non-allergic bronchial hyper-reactivity.
This article was published in Clin Allergy
and referenced in Journal of Allergy & Therapy