Author(s): Kliber A, Szkudelski T, Chichowska J, Kliber A, Szkudelski T, Chichowska J
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Abstract In the performed experiment the effect of alloxan on insulin secretion by in situ perfused rat pancreas was determined. It was found that alloxan added to the perfusion medium results in a sudden, short-term release of insulin. This effect is independent on the presence of glucose (6.66 mmol/l) in the perfusion medium. Furthermore, it was observed that glucose at 16.66 mmol/l concentration after alloxan perfusion does not stimulate insulin secretion.
This article was published in J Physiol Pharmacol
and referenced in Journal of Developing Drugs