alexa Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
Neurology

Neurology

Journal of Alzheimers Disease & Parkinsonism

Author(s): Hak S, Privat N, Adjou KT, Sazdovitch V, Dormont D, Hak S, Privat N, Adjou KT, Sazdovitch V, Dormont D,

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Abstract Prion related disorders are associated with the accumulation of a misfolded isoform (PrPsc) of the host-encoded prion protein, PrP. There is strong evidence for the involvement of unidentified co-factors in the PrP to PrPsc conversion process. In this study, we show alpha-synuclein-immunoreactive deposits in the central nervous system of various prion diseases (sporadic, iatrogenic and new variant Creutzfeldt-Jakob diseases, and experimental scrapie of hamsters). alpha-Synuclein accumulated close to PrPsc deposits but we did not observe strict colocalization of prion protein and alpha-synuclein immunoreactivities particularly in PrPsc plaques. alpha-Synuclein is thought to be a key player in some neurodegenerative disorders, is able to interact with amyloid structures and has known chaperone-like activities. Our results, in various prion diseases, suggest a role for alpha-synuclein in regulating PrPsc formation. This article was published in Acta Neuropathol and referenced in Journal of Alzheimers Disease & Parkinsonism

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