alexa Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer.


Journal of Addiction Research & Therapy

Author(s): Fujita S, Watanabe M, Kubota T, Teramoto T, Kitajima M

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Abstract We have investigated the expression of the integrin beta 1 subunit in 51 colorectal cancer tissues using immunoblotting and have determined the relationship between expression and clinical stage. In comparison with normal mucosa the pre-beta-subunit (the precursor of beta 1-subunit) was increased in 15 cases and decreased in two cases, and expression of the beta 1-subunit was decreased in two cases. These alterations of expression of the beta 1-subunit were significantly correlated with lymph node metastasis and depth of invasion (P < 0.01). These results suggest that integrin plays an important role in the invasion and metastasis of colorectal cancer.
This article was published in Cancer Lett and referenced in Journal of Addiction Research & Therapy

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