Author(s): Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, , Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S,
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Abstract An increased level of plasma thrombomodulin (TM) in alpha- and beta-thalassaemia was demonstrated using an enzyme-linked immunosorbent assay (ELISA). Nonsplenectomized patients with beta-thalassaemia/haemoglobin E (BE) had higher levels of TM than splenectomized cases (BE-S). Patients with leg ulcers (BE-LU) were found to have the highest increase in TM level. Appearance of larger platelets in all types of thalassaemic blood was observed indicating an increase in the number of younger platelets. These data indicate that injury of vascular endothelial cells is present in thalassaemic patients.
This article was published in Thromb Haemost
and referenced in Journal of Blood Disorders & Transfusion