alexa Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Viktornov A, Toserov E, Krizko M, Durackov Z

Abstract Share this page

Abstract Diabetes mellitus (DM) is associated with the alterations in the metabolism of copper (Cu), zinc (Zn), and magnesium (Mg). The aim of the present study was to investigate plasma levels of these elements in patients with DM and in healthy subjects. Association between glycated hemoglobin and levels of metals was also evaluated. We studied 36 subjects with DM (type 1, 11; type 2, 25) and 34 healthy subjects matched for age, sex, and duration of diabetes. Plasma concentrations of Cu, Zn, and Mg were measured by atomic absorption spectrometry. An imbalance in the levels of studied metals was observed in both type 1 and type 2 DM. We found higher levels of Cu (P < .001) and Cu/Zn ratio (P < .0001) and decreased levels of Zn (P < .01) and Mg (P < .0001) in patients with DM when compared with controls. Negative correlation between Cu and Zn (r = -0.626, P < .0001) was found in patients with DM. Glycated hemoglobin levels were positively correlated with Cu (r = 0.709, P < .001) and Cu/Zn ratio (r = 0.777, P < .001) and inversely correlated with Zn (r = - 0.684, P < .001) and Mg (r = -0.646, P < .001). In conclusion, patients with DM had altered metabolism of Cu, Zn, and Mg; and this may be related to increased values of glycated hemoglobin. We concluded that impaired metabolism of these elements may contribute to the progression of DM and diabetic complications. This article was published in Metabolism and referenced in Journal of Diabetes & Metabolism

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version