alexa Alternative splicing regulation impacts heart development.


Biochemistry & Physiology: Open Access

Author(s): Cooper TA

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Abstract SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. In this issue of Cell, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development. This article was published in Cell and referenced in Biochemistry & Physiology: Open Access

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