Author(s): Mishra M, Biswas UK, Jha DN, Khan AB
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Abstract We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar. Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen definitive doses of amphotericin 0.5 mg/kg infused in 5\% dextrose on alternate days. 48 (80\%) patients given pentamidine showed initial cure and 46 (77\%) showed definitive cure compared with 60 (100\%) and 59 (98\%) cases, respectively, on amphotericin (p < 0.001). Amphotericin also brought about quicker abatement of fever and more complete spleen regression.
This article was published in Lancet
and referenced in Journal of Computer Science & Systems Biology