alexa Amyotrophic lateral sclerosis: a neurovascular disease.
Psychiatry

Psychiatry

Journal of Depression and Anxiety

Author(s): GarbuzovaDavis S, Rodrigues MC, HernandezOntiveros DG, Louis MK, Willing AE,

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Abstract Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated pathogenesis. Compelling evidence indicates impairment of all neurovascular unit components including the blood-brain and blood-spinal cord barriers (BBB/BSCB) in both patients and animal models, leading to classification of ALS as a neurovascular disease. The present review provides an updated analysis of the normal and impaired BBB/BSCB, focusing on the ALS-altered barrier. Here we describe the roles of cellular components, tight junctions, transport systems, cell interactions, cytokines, matrix metalloproteinases, and free radicals in the BBB/BSCB disruption, along with recent evidence from experimental and clinical ALS studies. The BBB/BSCB is a promising research area in ALS and this review will reveal some aspects of microvascular pathology in ALS and hopefully provide ideas for the development of new therapeutic strategies. Copyright © 2011 Elsevier B.V. All rights reserved. This article was published in Brain Res and referenced in Journal of Depression and Anxiety

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