Author(s): Senovilla L, Vitale I, Martins I, Kepp O, Galluzzi L,
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Abstract One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.
This article was published in Oncoimmunology
and referenced in Journal of Cytology & Histology