alexa An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit.


Journal of Carcinogenesis & Mutagenesis

Author(s): Poate TW, Buchanan JA, Hodgson TA, Speight PM, Barrett AW,

Abstract Share this page

Abstract The diagnosis of oral epithelial dysplasia has traditionally been based upon histopathological evaluation of a full thickness biopsy specimen from lesional tissue. It has recently been proposed that cytological examination of "brush biopsy" samples is a non-invasive method of determining the presence of cellular atypia, and hence the likelihood of oral epithelial dysplasia. The present audit determined, retrospectively the sensitivity, specificity and positive and negative predictive values of the oral brush biopsy technique in the diagnosis of potentially malignant disease in a group of 112 patients attending a specialist Oral Medicine unit. The sensitivity of detection of oral epithelial dysplasia or squamous cell carcinoma of the oral brush biopsy system was 71.4\% while the specificity was 32\%. The positive predictive value of an abnormal brush biopsy result (positive or atypical) was 44.1\%, while the negative predictive value was 60\%. It is concluded that not all potentially malignant disease is detected with this non-invasive investigative procedure. This article was published in Oral Oncol and referenced in Journal of Carcinogenesis & Mutagenesis

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version