alexa An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus).
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Steroids & Hormonal Science

Author(s): Daan S, Damassa D, Pittendrigh CS, Smith ER

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Abstract Castration of mice in freerunning conditions (total darkness, DD) causes a reduction of running wheel activity in the beginning of the active period (alpha) and stimulates activity at the end of alpha. Simultaneously, the period (tau) of the freerunning rhythm is increased. Both effects are abolished by implantation of a Silastic capsule from which a physiological dose of testosterone is released at a constant rate. The results are tentatively explained by differential endocrine influences on two oscillating components in the pacemaker of the circadian activity rhythm.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Steroids & Hormonal Science

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